Caspase-9 Rabbit PolymAb®
Sizes: 20µl, 100µl
Catalogue Numbers: A22532-20, A22532-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Synonyms: MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6
GeneID: 842
Swiss Prot: P55211
Tested Applications: ELISA, IHC-P, IF/ICC
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 46kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 139-416 of Caspase-9 Rabbit PolymAb® (NP_001220.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Immunology Inflammation, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Cellular Location: apoptosome, Cytoplasm, Cytosol, Mitochondrion, Nucleus
Keywords: sc-22182, sc-8297, sc-8355, sc-7885, APAF 3, APAF3, Apoptotic protease Mch 6, CASP 9, CASP9, Caspase 9, Caspase 9/p35/p10, CASPASE 9c, Caspase9, Caspase-9, ICE LAP6, ICE like apoptotic protease 6, MCH6, APAF-3, ICE-LAP6, PPP1R56, caspase 9, caspase-9, ICE-like apoptotic protease 6, apoptotic protease MCH-6, apoptotic protease activating factor 3, apoptosis-related cysteine peptidase, protein phosphatase 1, regulatory subunit 56, P55211, 842
Symbol: CASP9
Category: Monoclonal Antibodies
Research Use Only