Caspr1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3721-20, A3721-100
Citations, Manuals and SDS Available upon request.
Background: The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
Synonyms: CHN3; P190; CASPR; NRXN4; CNTNAP; Caspr1
GeneID: 8506
Swiss-Prot: P78357
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 156kDa
Observed Molecular Weight: 190kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human Caspr11 (P78357).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Neuroscience, Cell Type Marker
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: U-87MG
Cellular Location: glutamatergic Synapse, paranodal Junction, Plasma Membrane, preSynaptic active zone
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.