Caspr2/CNTNAP2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19262-20, A19262-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability.
Synonyms: CDFE; NRXN4; AUTS15; CASPR2; PTHSL1; Caspr2/CNTNAP2
GeneID: 26047
Swiss-Prot: Q9UHC6
Reactivity: Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 148kDa
Observed Molecular Weight: 152kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1232-1331 of human Caspr2/CNTNAP2 (Q9UHC6).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Neuroscience, Cell Type Marker
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Projection, Membrane, Single-pass Type I Membrane Protein, Axon
Positive Samples: Mouse spinal cord, Rat brain
Keywords: sc-11178, sc-11179, sc-11180, CNTNAP2, AUTS15, CASPR2, CDFE, NRXN4, PTHSL1, contactin associated protein-like 2, contactin-associated protein-like 2, cell recognition molecule Caspr2, homolog of Drosophila neurexin IV, Q9UHC6, 26047, sc11178, sc 11178, sc11179, sc 11179, sc11180, sc 11180, Unconjugated, Caspr2/CNTNAP2
Symbol: CNTNAP2
Category: Monoclonal Antibodies
Research Use Only