Catenin-β Monoclonal Antibody (4F2)
Sizes: 50μL, 100μL
Catalogue Number: RA10527-50, RA10527-100
Citations, Manuals and MSDS Available upon request.
Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Store At/In: -20°C/1 year
Recommended Dilutions: WB: 1:1000-2000 IHC: 1:200-500 IF 1:200
Alternative Names: CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Background: catenin beta 1(CTNNB1) Homo sapiens The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],
Applications: WB; IF/ICC; IHC-p
Species Cross-Reactivity: Human; Mouse; Rat
Molecular Weight: 92
GeneID (Human): 1499
Protein MW (KDa): 92
SWISS: P35222
Source: Mouse
Research Use Only