Cathepsin B Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19005-20, A19005-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified.
Synonyms: KWE; APPS; CPSB; RECEUP; Cathepsin B
GeneID: 1508
Swiss-Prot: P07858
Reactivity: Human
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 38kDa
Observed Molecular Weight: 39-44kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-156 of human Cathepsin B (P07858).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Neuroscience
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Lysosome, Melanosome, Secreted, Extra Cellular Space
Positive Samples: HepG2
Keywords: 1508, sc-6493, sc-13985, sc-6490-R, APP secretase, APPS, cathepsin B, Cathepsin B1, CPSB, CTSB, amyloid precursor protein secretase, cathepsin B1, cysteine protease, P07858, Ctsb, Cathepsin B, APP Secretase, Amyloid Precursor Protein Secretase, Cysteine Protease, EC 3.4.22.1, cathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine protease
Symbol: CTSB
Category: Monoclonal Antibodies
Research Use Only