Cathepsin D Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19680-20, A19680-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Synonyms: CPSD; CLN10; HEL-S-130P; Cathepsin D
GeneID: 1509
Swiss-Prot: P07339
Reactivity: Human, Mouse
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 45kDa
Observed Molecular Weight: 28kDa/44kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 313-412 of human Cathepsin D (P07339).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Ubiquitin, Neuroscience
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Lysosome, Melanosome, Secreted, Extra Cellular Space
Positive Samples: A375, HepG2, MCF7, Mouse brain, Mouse kidney, Mouse spleen
Keywords: 1509, sc-6487, sc-6494, sc-6486, sc-6488, sc-10725, cathepsin D, CLN10, CPSD, CTSD, HEL-S-130P, ceroid-lipofuscinosis, neuronal 10, epididymis secretory sperm binding protein Li 130P, lysosomal aspartyl peptidase, lysosomal aspartyl protease, P07339, Cathepsin D, Ceroid-Lipofuscinosis, Neuronal 10, Epididymis Secretory Sperm Binding Protein Li 130P, Cathepsin D (Lysosomal Aspartyl Protease), Lysosomal Aspartyl Peptidase, Lysosomal Aspartyl Protease, EC 3.4.23.5
Symbol: CTSD
Category: Monoclonal Antibodies
Research Use Only