Cation-independent M6PR (IGF2R) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3762-20, A3762-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Synonyms: MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R; Cation-independent M6PR (IGF2R)
GeneID: 3482
Swiss-Prot: P11717
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 274kDa
Observed Molecular Weight: 274kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 2392-2491 of human Cation-independent M6PR (IGF2R) (NP_000867.3).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Signal transduction, Immunology inflammation, CDs, Cell intrinsic innate immunity signaling pathway
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: A-549, Mouse heart
Cellular Location: Lysosome Membrane, Single-pass Type I Membrane Protein
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.