Caveolin-2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4890-20, A4890-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).
Synonyms: CAV; Caveolin-2
GeneID: 858
Swiss-Prot: P51636
Reactivity: Human, Mouse
Calculated Molecular Weight: 18kDa
Observed Molecular Weight: 21kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caveolin-2 (P51636).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IP
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Adhesion, Endocrine Metabolism, Insulin Receptor Signaling Pathway, Cardiovascular
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, 293T, Mouse lung
Cellular Location: Cell Membrane, Cytoplasm, Golgi Apparatus Membrane, Membrane, Nucleus, Peripheral Membrane Protein, Caveola
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.