Caveolin-2 Rabbit Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS9903M-50, BS9903M-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P51636
Host: Rabbit
Reactivity: Human
Applications: WB, ICC/IF, IHC
All Applications: WB: 1:1000-1:2000
IHC/ICC/IF: 1:50-1:200
Background: Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated a and b, share a distinct but overlapping cellular distribution and differ by an N-terminal 31 amino acid sequence that is absent from the b isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.
Purification and Purity: Protein A affinity purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This antibody detects endogenous levels of Caveolin-2 and does not cross-react with related proteins.
Bioworld Molecular Weight: ~ 20 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of Caveolin-2 Rabbit mAb at 1:1000 dilution
Lane 1: HUVEC whole cell lysate, Immunohistochemical analysis of paraffin-embedded human cervix uteri tissue using anti-Caveolin-2 antibody.Counter stained with hematoxylin., ICC staining Caveolin-2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.
Alternative Name: Caveolin 2; CAV2; Caveolin2
Immunogen: Recombinant antibody.
Conjugate: Unconjugated
Modification: Unmodified