CBFA2T3 Monoclonal Antibody
Catalogue Numbers: MB66735-50, MB66735-100
Sizes: 50µl, 100µl
Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: O75081
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: ETO and ETO-2, which are alternatively designated MTG8 and MTG16, respectively, are members of the ETO transcription factor family. These transcription factors are characterized by a zinc-finger domain and four conserved domains, of which domain II is required for dimerization between family members. ETO and ETO-2 may function to mediate interactions between DNA binding proteins and transcriptional regulators, such as N-CoR. Frequently, the t(8;21) translocation of ETO produces the AML-1/ETO oncoprotein, which consists of the first 177 amino acids of AML-1 and all but the
first 30 amino acids of ETO. AML-1/ETO expression is observed in 12-15% of acute myelogenous, M2 subtype leukemias. The AML-1/ETO fusion proteins associate with multimeric N-CoR/mSin3/HDAC1 complexes, block differentiation and induce transcriptional repression by altering chromatin remodeling.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of CBFA2T3 protein.
Extra Notes: Western blot analysis of CBFA2T3 expression in Jurkat (A), CCRFCEM (B) whole cell lysates.
Bioworld Molecular Weight: ~ 72 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: MTG16; MTGR2; ZMYND4; Protein CBFA2T3; MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; hMTG16; Zinc finger MYND domain-containing protein 4
Immunogen: Recombinant fusion protein of human CBFA2T3. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified