CBL Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22994-20, A22994-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
Synonyms: CBL2; NSLL; C-CBL; RNF55; FRA11B; CBL
GeneID: 867
Swiss-Prot: P22681
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IP
Calculated Molecular Weight: 100kDa
Observed Molecular Weight: 110kDa
Immunogen: Recombinant protein of human CBL.
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Nuclear Receptor Signaling, Nuclear hormone receptors, Protein phosphorylation, Cancer, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Ubiquitin, Ubiquitin-Proteasome Signaling Pathway, Endocrine Metabolism, Insulin Receptor Signaling Pathway, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway
Recommended Dilutions: WB: 1:1000 - 1:5000 | IHC-P: 1:100 - 1:500 | IP: 0.5μg-4μg antibody for 400μg-600μg extracts of whole cells
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, Cytoplasm
Positive Samples: Raji, Mouse thymus, Rat testis
Keywords: 867, sc-170, CBL, C-CBL, CBL2, FRA11B, NSLL, RNF55, Cbl proto-oncogene, E3 ubiquitin-protein ligase CBL, Cas-Br-M (murine) ecotropic retroviral transforming sequence, E3 ubiquitin protein ligase, RING finger protein 55, RING-type E3 ubiquitin transferase CBL, casitas B-lineage lymphoma proto-oncogene, fragile site, folic acid type, rare, fra(11)(q23.3), oncogene CBL2, proto-oncogene c-Cbl, signal transduction protein CBL, P22681, Cbl Proto-Oncogene, Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence, E3 Ubiquitin Protein Ligase, Casitas B-Lineage Lymphoma Proto-Oncogene, RING-Type E3 Ubiquitin Transferase CBL, Signal Transduction Protein CBL, RING Finger Protein 55, Proto-Oncogene C-Cbl, Oncogene CBL2, Fragile Site, Folic Acid Type, Rare, Fra(11)(Q23.3), E3 Ubiquitin-Protein Ligase CBL, EC 2.3.2.27, c-Cbl
Symbol: CBL
Category: Monoclonal Antibodies
Research Use Only