CD11b Rabbit PolymAb®
Sizes: 20μL, 100μL
Catalogue Numbers: A26754PM-20, A26754PM-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Category: Monoclonal Antibodies
Applications: WB, IHC-P, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 127kDa
Observed Molecular Weight: 170kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 3684/16409
SWISS: P11215/P05555
Alternate Names: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:1000 - 1:6000 IHC-P, 1:200 - 1:800 IF/ICC, 1:200 - 1:800 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, G protein signaling, G-Protein-Coupled Receptors Signaling to MAPK Erk, PI3K-Akt Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Immunology Inflammation, CDs, Neuroscience, Cell T
NCBI Alias: ITGAM
Research Use Only