Claudin 18 mouse mAb (ABT158)
Sizes: 50µl, 100µl
Catalogue Numbers: RA12268-50, RA12268-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.155% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: IHC-p 1:100-500, IF 1:100-500
Purification Technology: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alternative Names: Claudin-18
Background: claudin 18 (CLDN18) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],
Applications: IHC-p, IF (paraffin section)
Species Cross-Reactivity: Human
GeneID (Human): 51208
SWISS: P56856
Source: Mouse
Immunogen: Synthesized peptide derived from human Claudin 18
Category: Monoclonal
Research Use Only