Collagen I/COL1A1 Rabbit PolymAb®
Sizes: 20μL, 100μL
Catalogue Numbers: A24112PM-20, A24112PM-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Category: Monoclonal Antibodies
Applications: WB, IF/ICC, IF-F, IF-P, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 139kDa
Observed Molecular Weight: 220kDa
Immunogen: Synthetic peptide .
Species: Human
GeneID: 1277
SWISS: P02452
Alternate Names: OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:6000 - 1:36000 IF/ICC, 1:200 - 1:2000 IF-F, 1:200 - 1:2000 IF-P, 1:200 - 1:2000 IHC-P, 1:2000 - 1:8000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction； Cytoskeleton / ECM ；Extracellular Matrix ；ECM Proteins ；Collagen；Stem Cells ；Mesenchymal Stem Cells ；Osteogenesis.
NCBI Alias: COL1A1
Research Use Only