ELN Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22733-20, A22733-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.
Synonyms: WS; WBS; SVAS; ADCL1; ELN
GeneID: 2006
Swiss-Prot: P15502
Reactivity: Human, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 68kDa
Observed Molecular Weight: 68kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ELN (NP_001265844.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Neuroscience
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:500 - 1:1000 | IF/ICC: 1:100 - 1:500
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Secreted, Extra Cellular Matrix, Extra Cellular Space
Positive Samples: Rat heart
Keywords: sc-17581, sc-17580, sc-25736, elastin, ELN, SVAS, Tropoelastin, WBS, WS, tropoelastin, P15502, 2006, ADCL1, sc17581, sc 17581, sc17580, sc 17580, sc25736, sc 25736, desmosine, FLJ38671, FLJ43523
Symbol: ELN
Category: Monoclonal Antibodies
Research Use Only