HRAS Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19619-20, A19619-100
Citations, Manuals and SDS Available upon request.
Background: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Synonyms: CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; HRAS
GeneID: 3265
Swiss-Prot: P01112
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 21kDa
Observed Molecular Weight: 21kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 90-189 of human HRAS (P01112).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Cancer, Signal Transduction, G protein signaling, Small G proteins, G-Protein-Coupled Receptors Signaling to MAPK Erk, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell differentiation, Cytoskeleton, Actins, Endocrine Metabolism, Insulin Receptor Signaling Pathway, Warburg Effect, Immunology Inflammation, B Cell Receptor Signaling Pathway, T Cell Receptor Signaling Pathway
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, Cytoplasm, Cytoplasmic Side, Golgi Apparatus, Golgi Apparatus Membrane, Lipid-anchor, Lipid-anchor, Nucleus, Perinuclear Region
Positive Samples: Mouse brain, Rat brain
Keywords: 3265, sc-32025, sc-32026, sc-520, sc-68743, C BAS/HAS, C H RAS, C HA RAS1, CTLO, GTPase HRas, H Ras 1, H RASIDX, Ha Ras, HAMSV, HRAS, HRAS1, K RAS, p21ras, RASH1, Transforming protein p21, C-BAS/HAS, C-H-RAS, C-HA-RAS1, H-RASIDX, HRas proto-oncogene, GTPase, GTP- and GDP-binding peptide B, Ha-Ras1 proto-oncoprotein, Harvey rat sarcoma viral oncogene homolog, Harvey rat sarcoma viral oncoprotein, Ras family small GTP binding protein H-Ras, c-has/bas p21 protein, c-ras-Ki-2 activated oncogene, p19 H-RasIDX protein, transformation gene: oncogene HAMSV, transforming protein p21, v-Ha-ras Harvey rat sarcoma viral oncogene homolog, P01112, HRas Proto-Oncogene, V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog, Harvey Rat Sarcoma Viral Oncogene Homolog, Transforming Protein P21, P21ras, Ras Family Small GTP Binding Protein H-Ras, Harvey Rat Sarcoma Viral Oncoprotein, Transformation Gene: Oncogene HAMSV, GTP- And GDP-Binding Peptide B, C-Ras-Ki-2 Activated Oncogene, Ha-Ras1 Proto-Oncoprotein, C-Has/Bas P21 Protein, P19 H-RasIDX Protein, H-Ras-1, C-H-Ras, Ha-Ras, GTPase HRAS
Symbol: HRAS
Category: Monoclonal Antibodies
Research Use Only