JNK2 Mouse mAb (4D2)
Sizes: 50µl, 100µl
Catalogue Numbers: RA11556-50, RA11556-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.59% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: IHC 1:50-200
Purification Technology: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Alternative Names: Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Background: mitogen-activated protein kinase 9 (MAPK9) Homo sapiens The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene&apos, s mouse counterpart suggest a key role in T-cell differentiation. Several alternative
Applications: IHC
Species Cross-Reactivity: Human, Mouse, Rat
GeneID (Human): 5601
SWISS: P45984
Source: Mouse
Immunogen: Synthesized peptide derived from human JNK2
Category: Monoclonal
Research Use Only