[KD Validated] Thymidylate synthase Rabbit mAb - A24168

[KD Validated] Thymidylate synthase Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A24168-20, A24168-100

Citations, Manuals and SDS Available upon request.

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

Synonyms: TS; TMS; DKCD; HST422; [KD Validated] Thymidylate synthase

GeneID: 7298

Swiss-Prot: P04818

Reactivity: Human

Tested Applications: ELISA, WB, IHC-P

Calculated Molecular Weight: 36kDa

Observed Molecular Weight: 36kDa

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human Thymidylate synthase(NP_001062.1).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Epigenetics Nuclear Signaling, Endocrine Metabolism, Nucleotide metabolism

Recommended Dilutions: WB: 1:2000 - 1:6000 | IHC-P: 1:100 - 1:500

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Cytoplasm, Mitochondrion, Mitochondrion Inner Membrane, Mitochondrion Matrix, Nucleus,

Positive Samples: 293T

Keywords: 7298, sc-48105, HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS, HST422, thymidylate synthase, P04818, Ts, Thymidylate Synthetase, Thymidylate Synthase, EC 2.1.1.45, sc48105, sc 48105, 病理诊断抗体, 病理诊断, [KD Validated] Thymidylate synthase

Symbol: TYMS

Category: Monoclonal Antibodies

Research Use Only