[KD Validated] TRAF2 Rabbit mAb - A19129

[KD Validated] TRAF2 Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A19129-20, A19129-100

Citations, Manuals and SDS Available upon request.

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Synonyms: TRAP; TRAP3; RNF117; MGC:45012; [KD Validated] TRAF2

GeneID: 7186

Swiss-Prot: Q12933

Reactivity: Human, Mouse, Rat

Tested Applications: ELISA, WB, IP

Calculated Molecular Weight: 53kDa/54kDa/55kDa/61kDa

Observed Molecular Weight: 53kDa

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Cancer, Signal Transduction, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Inhibition of Apoptosis, Autophagy, Growth factors, Death Receptor Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway, Cardiovascular

Recommended Dilutions: WB: 1:10000 - 1:60000 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Cytoplasm

Positive Samples: 293T, HeLa, C2C12, Mouse thymus, Rat thymus

Keywords: 7186, sc-7187, sc-876, sc-877, TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, RING-type E3 ubiquitin transferase TRAF2, tumor necrosis factor type 2 receptor associated protein 3, Q12933, TNF Receptor Associated Factor 2, RING-Type E3 Ubiquitin Transferase TRAF2, E3 Ubiquitin-Protein Ligase TRAF2, Tumor Necrosis Factor Type 2 Receptor Associated Protein 3, Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3, TNF Receptor-Associated Factor 2, EC 2.3.2.27, RNF117, TNF receptor-associated factor 2E3 ubiquitin-protein ligase TRAF2RING-type E3 ubiquitin transferase TRAF2tumor necrosis factor type 2 receptor associated protein 3, [KD Validated] TRAF2

Symbol: TRAF2

Category: Monoclonal Antibodies

Research Use Only