[KO Validated] active + pro Caspase-3 Rabbit mAb - A19654

[KO Validated] active + pro Caspase-3 Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A19654-20, A19654-100

Citations, Manuals and SDS Available upon request.

Background: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Synonyms: CPP32; SCA-1; CPP32B; -3

GeneID: 836

Swiss-Prot: P42574

Reactivity: Human, Mouse, Rat

Tested Applications: ELISA, WB

Calculated Molecular Weight: 32kDa

Observed Molecular Weight: 17kDa/32kDa/35kDa

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-175 of human Caspase-3 (P42574).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Death Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease

Recommended Dilutions: WB: 1:500 - 1:1000

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Cytoplasm

Positive Samples: 293T, Jurkat, L929, NIH/3T3, Mouse lung, Mouse liver, Rat liver

Keywords: 836, sc-22139, sc-22140, sc-1224, sc-1226, sc-1225, sc-6138, sc-98785, sc-7148, Apopain, CASP 3, CASP3, Caspase 3, Caspase 3/p17, Caspase3, CPP 32, CPP32, CPP32B, Cysteine protease CPP32, Protein Yama, SCA 1, SREBP cleavage activity 1, Caspase-3, SCA-1, caspase 3, caspase-3, CASP-3, CPP-32, PARP cleavage protease, apopain, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama, P42574, Apoptosis-Related Cysteine Peptidase, Apoptosis-Related Cysteine Protease, SREBP Cleavage Activity 1, Cysteine Protease CPP32, PARP Cleavage Protease, EC 3.4.22.56, Procaspase3, Active Caspase 3, active Caspase-3, Caspase-3 p12, active + pro Caspase 3 CPP32B, TNF, -3

Symbol: CASP3

Category: Monoclonal Antibodies

Research Use Only