[KO Validated] ACVR2A Rabbit mAb - A5237

[KO Validated] ACVR2A Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A5237-20, A5237-100

Citations, Manuals and SDS Available upon request.

Background: This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Synonyms: ACVR2; ACTRII; 2A

GeneID: 92

Swiss-Prot: P27037

Reactivity: Human, Mouse, Rat

Calculated Molecular Weight: 58kDa

Observed Molecular Weight: 80kDa

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR2A (P27037).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Tested Applications: ELISA, WB

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Recommended Dilutions: WB: 1:500 - 1:2000

Research Areas: Cancer, Signal Transduction, Kinase, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Endocrine Metabolism, Amino acid metabolism, Stem Cells

Modifications: Unmodified

Conjugate: Unconjugated

Positive Samples: 293T, A-549, SW481Mouse liver, Mouse testis, Mouse brain, Rat testis

Cellular Location: Membrane, Single-pass Type I Membrane Protein

Category: Monoclonal Antibodies

Citations, Manuals and SDS Available upon request.