[KO Validated] APP Rabbit mAb - A17911

[KO Validated] APP Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A17911-20, A17911-100

Citations, Manuals and SDS Available upon request.

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Synonyms: AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; PP

GeneID: 351

Swiss-Prot: P05067

Reactivity: Human, Mouse, Rat

Tested Applications: ELISA, WB, IF/ICC, IP

Calculated Molecular Weight: 87kDa

Observed Molecular Weight: 100-140kDa

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 671-770 of human APP (P05067).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Signal Transduction, G protein signaling, Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Neurodegenerative Diseases Markers

Recommended Dilutions: WB: 1:500 - 1:2000 | IF/ICC: 1:50 - 1:200 | IP: 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Membrane, Single-pass Type I Membrane Protein, Clathrin-coated Pit

Positive Samples: 293T, HeLa, U-87 MG, Mouse brain, Rat brain

Keywords: 351, sc-7496, sc-7497, sc-7498, sc-5399, sc-9129, A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta, PN-II, amyloid beta precursor protein, amyloid beta A4 protein, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid precursor protein, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, cerebral vascular amyloid peptide, peptidase nexin-II, preA4, protease nexin-II, testicular tissue protein Li 2, P05067, Amyloid Beta Precursor Protein, Amyloid Beta (A4) Precursor Protein, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, Amyloid Precursor Protein, Peptidase Nexin-II, Protease Nexin-II, Beta-Amyloid Precursor Protein, Testicular Tissue Protein Li 2, Amyloid-Beta Precursor Protein, Beta-Amyloid Peptide(1-40), Beta-Amyloid Peptide(1-42), Amyloid Beta A4 Protein, Amyloid-Beta A4 Protein, Beta-Amyloid Peptide, Alzheimer Disease, Amyloid beta A4Aβ42, amyloid beta A4 proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor proteincerebral vascular amyloid peptidepeptidase nexin-IIpreA4protease nexin-IItesticular tissue protein Li 2, PP

Symbol: APP

Category: Monoclonal Antibodies

Research Use Only