[KO Validated] Caspase-8 Rabbit mAb - A19549

[KO Validated] Caspase-8 Rabbit mAb

Sizes: 20µl, 100µl

Catalogue Numbers: A19549-20, A19549-100

Citations, Manuals and SDS Available upon request.

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Synonyms: CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; Caspase-8

GeneID: 841

Swiss-Prot: Q14790

Reactivity: Human

Tested Applications: ELISA, WB

Calculated Molecular Weight: 55kDa

Observed Molecular Weight: 57kDa

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-8 (Q14790).

Immunogen Species: Human

Host: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Ubiquitin, Death Receptor Signaling Pathway, Endocrine Metabolism, Immunology Inflammation, Toll-like Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases

Recommended Dilutions: WB: 1:500 - 1:2000

Modifications: Unmodified

Conjugate: Unconjugated

Cellular Location: Cytoplasm, Nucleus

Positive Samples: Jurkat, HepG2

Keywords: 841, sc-6136, sc-6135, sc-6134, sc-6133, sc-7890, Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5, ALPS2B, CAP4, Casp-8, caspase 8, caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein, MORT1-associated ced-3 homolog, apoptotic cysteine protease, apoptotic protease Mch-5, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, Q14790, Casp8, Apoptosis-Related Cysteine Peptidase, Apoptosis-Related Cysteine Protease, MORT1-Associated Ced-3 Homolog, ICE-Like Apoptotic Protease 5, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, FADD-Like ICE, FADD-Homologous ICE/CED-3-Like Protease, FADD-Homologous ICE/Ced-3-Like Protease, MACH-Beta-1/2/3/4 Protein, MACH-Alpha-1/2/3 Protein, EC 3.4.22.61, Caspase-8, CASP-8, TNF

Symbol: CASP8

Category: Monoclonal Antibodies

Research Use Only