Lamin A/C mouse mAb
Sizes: 50µl, 100µl
Catalogue Numbers: RA11596-50, RA11596-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: wb dilution 1:1000 icc dilution 1:200
Purification Technology: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Alternative Names: 70 kDa lamin , Cardiomyopathy dilated 1A (autosomal dominant) , CDCD1 , CDDC , CMD1A , CMT2B1 , EMD2 , FPL , FPLD , FPLD2 , HGPS , IDC , LAMIN A , lamin A/C , Lamin A/C like 1 , Lamin , LAMIN C , Lamin-A/C , LDP1 , LFP , LGMD1B , Limb girdle muscular dystrophy 1B (autosomal dominant) , LMN 1 , LMN A , LMN C , LMN1 , LMNA , LMNA_HUMAN , LMNC , LMNL1 , Prelamin A/C , PRO1 , Renal carcinoma antigen NY REN 32 , Renal carcinoma antigen NY-REN-32 , Renal carcinoma antigen NYREN32.
Background: lamin A/C (LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],
Applications: WB, IF/ICC
Species Cross-Reactivity: Human
GeneID (Human): 4000
SWISS: P02545
Source: Mouse
Immunogen: Purified recombinant human LMNA protein fragments expressed in E.coli.
Category: Monoclonal
Research Use Only