p53 Mouse mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A10610-20, A10610-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Synonyms: P53; BCC7; LFS1; BMFS5; TRP53; p53
GeneID: 7157
Swiss Prot: P04637
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Reactivity: Human
Calculated Molecular Weight: 44kDa
Observed Molecular Weight: 53kDa
Immunogen: A synthetic peptide of human p53
Immunogen Species: Human
Host: Mouse
Isotype: IgG1
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, DNA Damage Repair, Protein phosphorylation, Cancer, Tumor suppressors, p53 pathway, Signal Transduction, PI3K-Akt Signaling Pathway, ErbB-HER Signaling Pathway, MAPK-JNK Signaling Pathway, ATM Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Cell Cycle, Cell cycle inhibitors, Cell Cycle Control-G1 S Checkpoint, Cell Cycle Control-G2 M DNA Damage Checkpoint, Endocrine Metabolism, AMPK Signaling Pathway, Warburg Effect, Neuroscience, Neurodegenerative Diseases
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, SKOV3, MCF7
Cellular Location: Cytoplasm, Endoplasmic Reticulum, Mitochondrion Matrix, Nucleus, PML Body
Keywords: 7157, sc-1313, sc-1315, Antigen NY CO 13, Cellular tumor antigen p53, FLJ92943, LFS1, P53, Phosphoprotein p53, TP53, TRP53, tumor protein p53, Tumor suppressor p53, BCC7, cellular tumor antigen p53, antigen NY-CO-13, mutant tumor protein 53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, tumor protein 53, tumor supressor p53, P04637, Tumor Protein P53, Phosphoprotein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Cellular Tumor Antigen P53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Li-Fraumeni Syndrome, Tumor Supressor P53, Tumor Protein 53, p53p53, BMFS5, sc1313, sc 1313, sc1315, sc 1315, p53
Symbol: TP53
Category: Monoclonal Antibodies
Research Use Only