p63 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19652-20, A19652-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.
Synonyms: AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
GeneID: 8626
Swiss-Prot: Q9H3D4
Reactivity: Human, Mouse
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 77kDa
Observed Molecular Weight: 52-68kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-203 of human p63 (Q9H3D4).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Cancer, Tumor suppressors, p53 pathway, Cell Biology Developmental Biology, Apoptosis, Stem Cells
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Nucleus
Positive Samples: 293T cells, DU145 cells, MCF7 cells, Mouse thymus, Mouse skeletal muscle
Keywords: 8626, AIS, B(p51A), B(p51B), CUSP, EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP63, TP73L, Tumor protein 63, tumor protein p63, Tumor protein p73 like, tumor protein 63, amplified in squamous cell carcinoma, chronic ulcerative stomatitis protein, keratinocyte transcription factor KET, transformation-related protein 63, tumor protein p53-competing protein, Q9H3D4, Tumor Protein P63, P73L, P63, Chronic Ulcerative Stomatitis Protein, Keratinocyte Transcription Factor KET, Tumor Protein P53-Competing Protein, Transformation-Related Protein 63, Tumor Protein P73-Like, P73H, P40, P51, Amplified In Squamous Cell Carcinoma, Tumor Protein P53-Like, Tumor Protein 63, B(P51A), B(P51B), P53CP, 病理诊断抗体, IHC pathology, 病理诊断, 病理診斷抗體, 病理診斷
Symbol: TP63
Category: Monoclonal Antibodies
Research Use Only