PABPN1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A1735-20, A1735-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Synonyms: OPMD; PAB2; PABII; PABP2; PABP-2; PABPN1
GeneID: 8106
Swiss-Prot: Q86U42
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 31kDa/33kDa
Observed Molecular Weight: 50kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (Q86U42).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, RNA Binding
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Nucleus
Positive Samples: HeLa, HepG2, Raji, Mouse lung, Mouse brain, Rat brain
Keywords: PABPN1, OPMD, PAB2, PABII, PABP-2, PABP2, poly(A) binding protein nuclear 1, polyadenylate-binding protein 2|poly(A) binding protein 2|poly(A) binding protein II, Q86U42
Symbol: PABPN1
Category: Monoclonal Antibodies
Research Use Only