PAR4 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4983-20, A4983-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
Synonyms: PAR4; Par-4
GeneID: 5074
Swiss-Prot: Q96IZ0
Reactivity: Human, Mouse
Calculated Molecular Weight: 37kDa
Observed Molecular Weight: 41kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 241-340 of human PAR4 (Q96IZ0).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Endocrine Metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, SW620, 293T, Mouse lung
Cellular Location: Cytoplasm, Nucleus
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.