PARP1 Mouse mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A18303-20, A18303-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Synonyms: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP; PARP1
GeneID: 142
Swiss Prot: P09874
Tested Applications: ELISA, WB
Reactivity: Human, Mouse
Calculated Molecular Weight: 113kDa
Observed Molecular Weight: 89kDa/130kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 662-1014 of human PARP1 (NP_001609.2)
Immunogen Species: Human
Host: Mouse
Isotype: IgG2a, Kappa
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, DNA Damage Repair, RNA Binding, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Centrosome, Death Receptor Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway
Positive Samples: Jurkat, HeLa, NIH/3T3
Cellular Location: Nucleus, Nucleolus
Keywords: 142, sc-1561, sc-1562, sc-25780, sc-7150, ADPRT, ADPRT 1, ADPRT1, pADPRT 1, PARP, PARP 1, PARP1, poly (ADP ribose) polymerase 1, Poly [ADP ribose] polymerase 1, Poly[ADP ribose] synthase 1, PPOL, ARTD1, PARP-1, pADPRT-1, poly(ADP-ribose) polymerase 1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), ADP-ribosyltransferase NAD(+), ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthase 1, P09874, Poly(ADP-Ribose) Polymerase 1, ADP-Ribosyltransferase (NAD+, Poly (ADP-Ribose) Polymerase), ADP-Ribosyltransferase Diphtheria Toxin-Like 1, Poly (ADP-Ribose) Polymerase Family, Member 1, NAD(+) ADP-Ribosyltransferase 1, Poly[ADP-Ribose] Synthase 1, Poly [ADP-Ribose] Polymerase 1, ADP-Ribosyltransferase NAD(+), Poly(ADP-Ribosyl)Transferase, Poly(ADP-Ribose) Synthetase, EC 2.4.2.30, PADPRT-1, Cleaved PARP, PARP1
Symbol: PARP1
Category: Monoclonal Antibodies
Research Use Only