PARP1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19596-20, A19596-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Synonyms: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP; PARP1
GeneID: 142
Swiss-Prot: P09874
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 113kDa
Observed Molecular Weight: 89kDa/113kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human PARP1 (P09874).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, DNA Damage Repair, RNA Binding, Signal Transduction, Cell Biology Developmental Biology, Cell Cycle, Centrosome, Death Receptor Signaling Pathway, Immunology Inflammation, NF-kB Signaling Pathway
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Nucleus, Nucleolus
Positive Samples: Jurkat+Staurosporine
Keywords: 142, sc-1561, sc-1562, sc-25780, sc-7150, ADPRT, ADPRT 1, ADPRT1, pADPRT 1, PARP, PARP 1, PARP1, poly (ADP ribose) polymerase 1, Poly [ADP ribose] polymerase 1, Poly[ADP ribose] synthase 1, PPOL, ARTD1, PARP-1, pADPRT-1, poly(ADP-ribose) polymerase 1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), ADP-ribosyltransferase NAD(+), ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthase 1, P09874, Poly(ADP-Ribose) Polymerase 1, ADP-Ribosyltransferase (NAD+, Poly (ADP-Ribose) Polymerase), ADP-Ribosyltransferase Diphtheria Toxin-Like 1, Poly (ADP-Ribose) Polymerase Family, Member 1, NAD(+) ADP-Ribosyltransferase 1, Poly[ADP-Ribose] Synthase 1, Poly [ADP-Ribose] Polymerase 1, ADP-Ribosyltransferase NAD(+), Poly(ADP-Ribosyl)Transferase, Poly(ADP-Ribose) Synthetase, EC 2.4.2.30, PADPRT-1, Cleaved PARP, PARP1 ADPRT 1
Symbol: PARP1
Category: Monoclonal Antibodies
Research Use Only