PAX6 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19099-20, A19099-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain.
Synonyms: AN; PAX6
GeneID: 5080
Swiss-Prot: P26367
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB, IHC-P
Calculated Molecular Weight: 47kDa/48kDa
Observed Molecular Weight: 47kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 323-422 of human PAX6 (NP_000271.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Signal Transduction, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Neuroscience, Cell Type Marker, Stem Cells
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Nucleus
Positive Samples: HeLa, 293T, Mouse brain
Keywords: 5080, sc-7750, sc-7751, sc-11357, AN, AN2, Aniridia type II protein, D11S812E, MGDA, Oculorhombin, paired box 6, Paired box protein Pax 6, PAX6, WAGR, ASGD5, FVH1, paired box protein Pax-6, aniridia type II protein, oculorhombin, paired box homeotic gene-6, P26367, Paired Box 6, Aniridia Type II Protein, Paired Box Gene 6 (Aniridia, Keratitis), Paired Box Homeotic Gene-6, Paired Box Protein Pax-6, Aniridia, Keratitis, paired box protein Pax-6aniridia type II proteinoculorhombinpaired box homeotic gene-6
Symbol: PAX6
Category: Monoclonal Antibodies
Research Use Only