PCSK9 Mouse Monoclonal Antibody (5G4)
Sizes: 50μL, 100μL
Catalogue Number: RA11824-50, RA11824-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.84% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: IHC-p1:50-200 ,WB 1:1000-2000
Alternative Names: Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)
Background: proprotein convertase subtilisin/kexin type 9(PCSK9) Homo sapiens This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
Applications: IHC-p; WB
Species Cross-Reactivity: Human; Mouse; Rat
Molecular Weight: 74
GeneID (Human): 255738
Protein MW (KDa): 74
SWISS: Q8NBP7
Source: Mouse
Research Use Only