PCSK9 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A25215-20, A25215-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Synonyms: PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; proprotein convertase subtilisin/kexin type 9
GeneID: 255738
Swiss-Prot: Q8NBP7
Reactivity: Human, Mouse
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 20kDa/74kDa
Observed Molecular Weight: 65kDa,80kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 31-692 of human PCSK9 (NP_777596.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics & Nuclear Signaling, RNA Binding, Cancer, Signal Transduction, Cell Biology & Developmental Biology, Apoptosis, Ubiquitin, Endocrine & Metabolism, Amino acid metabolism, Lipid Metabolism, Cholesterol Metabolism, Stem Cells, Neural Stem Cells, Cardiovascular, Lipids,
Recommended Dilutions: WB: 1:1000 - 1:5000 | IHC-P: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell surface, Cytoplasm, Endoplasmic Reticulum, Endosome, Golgi Apparatus, Lysosome, Secreted
Positive Samples: HeLa
Keywords: sc-34696, sc-34693, sc-34692, sc-66996, FH3, HCHOLA3, LDLCQ1, NARC 1, NARC1, PC9, PCSK9, Proprotein convertase 9, NARC-1, proprotein convertase subtilisin/kexin type 9, convertase subtilisin/kexin type 9 preproprotein, neural apoptosis regulated convertase 1, subtilisin/kexin-like protease PC9, Q8NBP7, 255738
Symbol: PCSK9
Category: Monoclonal Antibodies
Research Use Only