PD-L1/CD274 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A20270-20, A20270-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Synonyms: B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; PD-L1/CD274
GeneID: 29126
Swiss Prot: Q9NZQ7
Tested Applications: ELISA, Inhibition, FC
Reactivity: Human
Calculated Molecular Weight: 33kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PD-L1/CD274 (Q9NZQ7)
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: ≥95% purity by SDS-PAGE
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: Elisa: 1:500 - 1:2000 | FC: 1:50 - 1:200
Research Areas: Immunology Inflammation, CDs
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Membrane, EndoMembrane System, Single-pass Type I Membrane Protein,
Keywords: 29126, sc-19090, sc-19091, sc-50298, B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1, B7-H, programmed cell death 1 ligand 1, CD274 antigen, Q9NZQ7, CD274 Molecule, CD274 Antigen, B7 Homolog 1, Programmed Cell Death 1 Ligand 1, PDCD1 Ligand 1, Programmed Death Ligand 1, B7-H1, B7H, sc19090, sc 19090, sc19091, sc 19091, sc50298, sc 50298
Symbol: CD274
Category: Monoclonal Antibodies
Research Use Only