PDGFB Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22036-20, A22036-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
Synonyms: SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; PDGFB
GeneID: 5155
Swiss-Prot: P01127
Reactivity: Mouse
Tested Applications: ELISA, IF/ICC
Calculated Molecular Weight: 27kDa
Observed Molecular Weight: Refer to figures
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 142-241 of human PDGFB (NP_002599.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Signal Transduction, Cell Biology, Developmental Biology, Growth factors, Endocrine Metabolism, Immunology Inflammation, Cytokines, Cardiovascular, Angiogenesis, Blood, Serum Proteins, Hypoxia, Heart, Cardiovascular diseases, Heart disease
Recommended Dilutions: IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Secreted
Positive Samples: NIH/3T3
Keywords: 5155, sc-7878, sc-127, PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B, platelet-derived growth factor subunit B, PDGF subunit B, PDGF, B chain, becaplermin, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), platelet-derived growth factor, beta polypeptide (oncogene SIS), proto-oncogene c-Sis, P01127, Platelet Derived Growth Factor Subunit B, Becaplermin, Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (V-Sis) Oncogene Homolog), Platelet-Derived Growth Factor Beta Polypeptide, Platelet-Derived Growth Factor B Chain, Proto-Oncogene C-Sis, PDGF Subunit B, Platelet-Derived Growth Factor, Beta Polypeptide (Oncogene SIS), Platelet-Derived Growth Factor Subunit B, Platelet-Derived Growth Factor 2, B Chain, Oncogene SIS, C-Sis, FLJ12858, csis, c sis, PDGF 2, sc7878, sc 7878, sc127, sc 127
Symbol: PDGFB
Category: Monoclonal Antibodies
Research Use Only