PE Mouse Anti-human CD28 Monoclonal Antibody
Sizes: 25 tests, 100µl
Catalogue Numbers: MB8503P-25, MB8503P-100
Swiss-Prot: P10747
Host: Mouse
Reactivity: Human
Applications: FC
All Applications: FC:5ul per test
Background: CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).
CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive (expression is independent of environmental factors).CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.
Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification and Purity: Protein A affinity purified
Storage and Stability: Store at 4°C . Avoid freezed.
Specificity: This antibody detects Extracellular domain of human CD28.
Extra Notes: Flow cytometry analysis of human monocytes.
Bioworld Molecular Weight: N/A
Note: For research use only, not for use in diagnostic procedure.
Conjugate: Unconjugated
Modification: Unmodified