PE Rabbit anti-Human STAT3 Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A28383-100, A28383-200, A28383-500
Citations, Manuals and MSDS Available upon request.
Background: The STAT3 transcription factor is a critical signaling molecule for numerous cytokine and growth factor receptors and is essential for murine fetal development. As an 88 kD member of the STAT (Signal Transducer and Activator of Transcription) protein family, STAT3 is phosphorylated in response to cytokine receptor-associated kinase activity. STAT3 is activated primarily by phosphorylation at Tyr705, which induces its dimerization, nuclear translocation, and DNA binding. STAT3 can form both homodimers and heterodimers and is involved in the activation of genes required for cell growth and the regulation of apoptosis.
Category: Monoclonal Antibodies
Application: FC (intra)
Cross Reactivity: Human
Protein Weight: 88 kDa Immunogen: Synthetic peptide.
Species: Human
GeneID: 6774
SWISS: P40763
Alternate Names: APRF; HIES; ADMIO; ADMIO1
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Signal Transduction, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Inhibition of Apoptosis, Microtubules, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Stem Cells, Embryonic Stem Cells, Cardiovascular, Heart, Cardiogenesis, Hypertrophy
NCBI Alias: STAT3
Modifications: Unmodified
Conjugate: PE. Ex:565nm. Em:574nm.
Clone Number Info: ARC70808
Research Use Only