PEG10 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Number: RA11832-50, RA11832-100
Citations, Manuals and MSDS Available upon request.
Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Store At/In: -20°C/1 year
Recommended Dilutions: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Alternative Names: PEG10; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-lik
Background: paternally expressed 10(PEG10) Homo sapiens This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis.
Applications: WB
Species Cross-Reactivity: Human; Mouse; Pig; Rabbit
GeneID (Human): 23089
SWISS: Q86TG7
Source: Mouse
Research Use Only