PEG10 mouse mAb
Sizes: 50µl, 100µl
Catalogue Numbers: RA11835-50, RA11835-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store at: -20°C/1 year
Recommended Dilution: wb 1:1000
Purification Technology: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Alternative Names: AA407948, Edr, Embryonal carcinoma differentiation regulated, Embryonal carcinoma differentiation-regulated protein, HB 1, HB1, KIAA1051, Mammalian retrotransposon-derived protein 2, Mar2, Mart2, MEF3 like 1, MEF3-like protein 1, MEF3L, MEF3L1, MyEF 3, Myelin expression factor 3-like protein 1, Paternally expressed 10, Paternally expressed gene 10 ORF1, Paternally expressed gene 10 protein, Peg10, PEG10 protein, PEG10_HUMAN, Putative uncharacterized protein PEG10, Retrotransposon gag domain containing 3, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Retrotransposon-derived protein PEG10, RGAG3, Ty3/Gypsy-like protein.
Background: paternally expressed 10 (PEG10) Homo sapiens This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1, and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis.
Applications: WB, IP
Species Cross-Reactivity: Human
GeneID (Human): 23089
SWISS: Q86TG7
Source: Mouse
Immunogen: Purified recombinant human PEG10 protein fragments expressed in E.coli.
Category: Monoclonal
Research Use Only