Pellino 1 Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: MB11393-50, MB11393-100
Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Swiss-Prot: Q96FA3
Host: Rabbit
Reactivity: Human, Rat
Applications: WB,IP
All Applications: WB: 1/500-1/1000 IP: 1/20
Background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).
Purification and Purity: Affinity Purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Pellino 1 in rat Brain, JurkatLysates using Pellino 1 antibody.
Bioworld Molecular Weight: Calculated MW: 46 kDa; Observed MW: 46 kDa
Specificity: IgG
Alternative Name: Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1
Immunogen: Recombinant protein of human Pellino 1
Conjugate: Unconjugated
Modification: Unmodified