PENK Monoclonal Antibody
Catalogue Numbers: MB66762-50, MB66762-100
Sizes: 50µl, 100µl
Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Swiss-Prot: P01210
Host: Mouse
Reactivity: Human
Applications: WB
All Applications: WB (1/500 - 1/1000)
Background: The corticotropin-lipotropin protein, also designated pro-opiomelanocortin,belongs to the POMC family of proteins. Specific cleavages by enzymes at certain basic paired residues yield various processed active peptides. The corticotropin-lipotropin protein contains synenkephalin, Leu-enkephalin, NPP, a-, b- and g-melanotropin (MSH), adrenocorticotropic hormone (ACTH), lipotropin b and g, b-endorphin and Met-enkephalin processed active peptides.b-endorphin and Met-enkephalin are endogenous opiates while ACTH is crucial for adrenal gland stimulation to release cortisol. Met/Leu-enkephalins also function in pain perception and response to stress. MSH increased melanin production in melanocytes which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP-K and PI3-K pathways.
Purification and Purity: This antibody is purified through a protein G column.
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Recognizes endogenous levels of PENK protein.
Extra Notes: Western blot analysis of PENK expression in T47D (A) whole cell lysates.
Bioworld Molecular Weight: ~ 34 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Proenkephalin-A
Immunogen: Recombinant fusion protein of human PENK. The exact sequence is proprietary.
Conjugate: Unconjugated
Modification: Unmodified