Pepsinogen II (PG II) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22282-20, A22282-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Synonyms: PEPC; PGII; Pepsinogen II (PG II)
GeneID: 5225
Swiss Prot: P20142
Tested Applications: ELISA, IHC-P
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 42kDa
Observed Molecular Weight: Refer to figures
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-388 of human Pepsinogen II (PG II) (NP_002621.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200
Research Areas: Cancer, Tumor biomarkers, Signal Transduction, Endocrine Metabolism, Amino acid metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Secreted
Keywords: 5225, sc-51185, sc-51190, sc-51188, sc-99080, Gastricsin, Pepsinogen C, Pepsinogen II, PEPSINOGEN, GROUP II, PGC, Progastricsin, progastricsin (pepsinogen C), PEPC, PGII, progastricsin, gastricsin, pepsin C, pepsinogen C, pepsinogen group II, preprogastricsin, P20142, Progastricsin (Pepsinogen C), Pepsinogen Group II, Preprogastricsin, EC 3.4.23.3, Pepsin C, sc51185, sc 51185, sc51190, sc 51190, sc51188, sc 51188, sc99080, sc 99080, Pepsinogen II (PG II)
Symbol: PGC
Category: Monoclonal Antibodies
Research Use Only