PER2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A5107-20, A5107-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Synonyms: FASPS; FASPS1; PER2
GeneID: 8864
Swiss-Prot: O15055
Reactivity: Human
Calculated Molecular Weight: 137kDa
Observed Molecular Weight: 140kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PER2 (O15055).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, ChIP
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | ChIP: 5μg antibody for 10μg-15μg of Chromatin
Research Areas: Epigenetics Nuclear Signaling, Cancer, Signal Transduction, Endocrine Metabolism, Neuroscience, Cardiovascular, Blood
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: BxPC-3, HeLa
Cellular Location: Cytoplasm, Nucleus, NucleolusPerinuclear Region
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.