Peroxiredoxin 3 (PRDX3) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2398-20, A2398-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
Synonyms: AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III; Peroxiredoxin 3 (PRDX3)
GeneID: 10935
Swiss-Prot: P30048
Reactivity: Human, Mouse
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Calculated Molecular Weight: 28kDa
Observed Molecular Weight: 25kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 157-256 of human Peroxiredoxin 3 (PRDX3) (PRDX3) (P30048).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Immunology Inflammation, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease, Cardiovascular, Heart, Cardiovascular diseases, Heart disease
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Mitochondrion, Cytoplasm, Endosome
Positive Samples: Hep G2, MCF7, U-87MG, Mouse liver
Keywords: PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III, peroxiredoxin 3, thioredoxin-dependent peroxide reductase, mitochondrial|antioxidant protein 1|peroxiredoxin III|protein MER5 homolog, P30048, Peroxiredoxin 3 (PRDX3)
Symbol: PRDX3
Category: Monoclonal Antibodies
Research Use Only