PKC zeta Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A23777-20, A23777-100
Citations, Manuals and SDS Available upon request.
Background: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: PRKCZ; PKC-ZETA; PKC2; protein kinase C zeta; PKC zeta
GeneID: 5590
Swiss-Prot: Q05513
Reactivity: Human
Tested Applications: ELISA, WB
Calculated Molecular Weight: 46kDa/56kDa/67kDa
Observed Molecular Weight: 75kDa
Immunogen: Recombinant protein of human PKC zeta.
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Signal Transduction, G protein signaling, G2/M DNA Damage Checkpoint, Kinase, Serine/threonine kinases, Phospholipase Signaling Pathway, Protein Kinase C Signaling Pathway, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology & Developmental Biology, Apoptosis, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, TGF-b-Smad Signaling Pathway, Endocrine & Metabolism, Insulin Receptor Signaling Pathway, Immunology & Inflammation, B Cell Receptor Signaling Pathway, NF-kB Signaling Pathway,
Recommended Dilutions: WB: 1:500 - 1:1000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cell Junction, Cytoplasm, Endosome
Positive Samples: 293T, Hep G2
Keywords: PKC2, PKC-ZETA, PKC zeta
Symbol: PRKCZ
Category: Monoclonal Antibodies
Research Use Only