PLC gamma 1 (PLCG1) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A8899-20, A8899-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLC gamma 1 (PLCG1)
GeneID: 5335
Swiss-Prot: P19174
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 149kDa
Observed Molecular Weight: 150kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 710-832 of human PLC gamma 1 (PLC gamma 1 (PLCG1)) (P19174).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Cytoskeleton, Actins, Endocrine Metabolism, Lipid Metabolism, Immunology Inflammation, T Cell Receptor Signaling Pathway, Cardiovascular, Angiogenesis, Lipids
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, PC-12, NIH/3T3, Mouse lung, Mouse brain
Cellular Location: Cell Projection, Lamellipodium, ruffle
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.