PLC gamma 2 (PLCG2) Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A5182-20, A5182-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
Synonyms: FCAS3; APLAID; PLC-IV; PLC-gamma-2; PLC gamma 2 (PLCG2)
GeneID: 5336
Swiss-Prot: P16885
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 148kDa
Observed Molecular Weight: 150kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 700-800 of human PLC gamma 2 (PLC gamma 2 (PLCG2)) (P16885).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Protein phosphorylation, Cancer, Signal Transduction, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Cytoskeleton, Actins, Endocrine Metabolism, Lipid Metabolism, Immunology Inflammation, B Cell Receptor Signaling Pathway, Cardiovascular, Angiogenesis, Lipids
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Raji
Cellular Location: Cytoplasm, Cytosol, Extra Cellular Exosome, Perinuclear Region of Cytoplasm, Plasma Membrane, Ruffle Membrane
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.