Plectin Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A19743-20, A19743-100
Citations, Manuals and SDS Available upon request.
Background: Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .
Synonyms: HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17; Plectin
GeneID: 5339
Swiss Prot: Q15149
Tested Applications: ELISA, IHC-P
Reactivity: Human, Rat
Calculated Molecular Weight: 532kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4609 of human Plectin (NP_958782.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: IHC-P: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Intermediate Filaments
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Cytoplasm, Cytosol, Extra Cellular Exosome, Focal Adhesion, Intermediate filament Cytoskeleton, Mitochondrial Outer Membrane, Perinuclear Region of Cytoplasm, Plasma Membrane, Z Disc
Keywords: PLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, plectin|hemidesmosomal protein 1|plectin 1, intermediate filament binding protein 500kDa, Q15149, Plectin
Symbol: PLEC
Category: Monoclonal Antibodies
Research Use Only