PLOD2/LH2 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22040-20, A22040-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: LH2; TLH; BRKS2; PLOD2/LH2
GeneID: 5352
Swiss-Prot: O00469
Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Calculated Molecular Weight: 85kDa
Observed Molecular Weight: 100kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human PLOD2/LH2 (NP_000926.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Research Areas: Epigenetics Nuclear Signaling, Cancer, Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Extracellular Matrix, Endocrine Metabolism
Recommended Dilutions: WB: 1:10000 - 1:30000
Modifications: Unmodified
Conjugate: Unconjugated
Cellular Location: Lumenal side, Peripheral Membrane Protein, Rough Endoplasmic Reticulum Membrane
Positive Samples: U-87MG, DU145, Molt-4, Mouse uterus, Rat uterus
Keywords: 5352, sc-50067, sc-50068, LH2, Lysyl hydroxylase 2, PLOD2, TLH, PLOD2-Specific, BRKS2, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, lysine hydroxylase 2, lysyl hydroxlase 2, lysyl hydroxylase 2, procollagen-lysine 5-dioxygenase, telopeptide lysyl hydroxylase, O00469, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 2, Procollagen-Lysine 5-Dioxygenase, Lysyl Hydroxylase 2, Lysyl Hydroxlase 2, 2-Oxoglutarate 5-Dioxygenase (Lysine Hydroxylase) 2, Telopeptide Lysyl Hydroxylase, Lysine Hydroxylase 2, EC 1.14.11.4, sc50067, sc 50067, sc50068, sc 50068, PLOD2/LH2
Symbol: PLOD2
Category: Monoclonal Antibodies
Research Use Only