PMP70/ABCD3 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A4172-20, A4172-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: ZWS2; ABC43; CBAS5; PMP70; PXMP1; PMP70/ABCD3
GeneID: 5825
Swiss-Prot: P28288
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 75kDa
Observed Molecular Weight: 70kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 560-659 of human PMP70/ABCD3 (P28288).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Lipid Metabolism, Neuroscience, Neurodegenerative Diseases, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HepG2, A-549, Mouse liver, Mouse kidney, Rat liver
Cellular Location: Cytosol, Mitochondrion, peroxisomal Matrix, peroxisome
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.